Visionsource
FacebookYoutubeGoogleFlickr

Text for an Appointment
or call (214) 865-6266

Pay Online

What Happened to Those Dilation Reversal Drops?


Getting your eyes dilated can be inconvenient – dilation makes the eyes light sensitive which can make it difficult to read books or use phones and computers for a couple of hours.

So wouldn’t it be great to have another drop to reverse the effects of dilation?

On Dec. 31, 1990, dapiprazole, under the trade name Rev-Eyes, was approved by the FDA and thought to be the answer to all the post-dilation problems. It was marketed for treatment of medically-induced dilation by stimulating pupillary constriction and restoration of accommodative function for reading.

In clinical practice, dapiprazole took between one to two hours to return pupils to pre-dilation size.

Side effects such as stinging upon instillation, conjunctival hyperemia (redness of eye), headache, and a few instances of ptosis (lid drooping), with a possible additional dollar cost to patients, seemed to lessen dapiprazole’s overall clinical benefit.

Reading ability returned in approximately 43 minutes with dapiprazole vs 66 minutes without the drop (Optom Vis Sci 1994 May; 71(5):319-22). The main complaint that people had after using dapiprazole was the conjunctival hyperemia, which lasted more than three hours. The other issue was that dapiprazole was costly, so some practitioners included an additional charge for the reversal of dilation to offset the cost.

The full adverse reaction profile according to Drugs.com is as follows:

"Adverse Reactions: In controlled studies, the most frequent reaction to dapiprazole was conjunctival injection lasting 20 minutes in over 80% of patients. Burning on instillation of dapiprazole hydrochloride ophthalmic solution was reported in approximately half of all patients. Reactions occurring in 10% to 40% of patients included ptosis, lid erythema, lid edema, chemosis, itching, punctate keratitis, corneal edema, browache, photophobia and headaches. Other reactions reported less frequently included dryness of eyes, tearing and blurring of vision."

Currently, Rev-Eyes is off the market. The FDA has stated that Rev-Eyes was not withdrawn from the market for reasons of safety or effectiveness.

At this time, there is nothing available for reversal of dilation. People who get dilated will still need to wear their sunglasses and to put off reading for a couple of hours until the effects of the dilation drops wear off.

 

Article contributed by Dr. Jane Pan

This blog provides general information and discussion about eye health and related subjects. The words and other content provided on this blog, and in any linked materials, are not intended and should not be construed as medical advice. If the reader or any other person has a medical concern, he or she should consult with an appropriately licensed physician. The content of this blog cannot be reproduced or duplicated without the express written consent of Eye IQ.

Office Details

  • Office Interior

    6851 Virginia Parkway,
    Suite #101
    McKinney, TX 75071-0990
    Phone: (214) 865-6266

    Map
    Office Hours
    Mon, Wed, Fri: 8:00am - 5:00pm
    Tue, Thur: 7:00am - 7:00pm

    2019 Best Of Logo long

Latest Vision News

What to Know Before Your First Eye Injection

A common in-office procedure is an eye injection for treatment of various eye conditions, such as wet macular degeneration, diabetic retinopathy, or vein occlusion.  

It is normal to be anxious prior to your first eye injection but knowing...

Read more...